Review
doi: 10.1038/nrn3311.
Calcium channel auxiliary α2δ and β subunits: trafficking and one step beyond
Affiliations
- PMID: 22805911
- DOI: 10.1038/nrn3311
Item in Clipboard
Review
Calcium channel auxiliary α2δ and β subunits: trafficking and one step beyond
Nat Rev Neurosci.
.
Abstract
The voltage-gated calcium channel α(2)δ and β subunits are traditionally considered to be auxiliary subunits that enhance channel trafficking, increase the expression of functional calcium channels at the plasma membrane and influence the channels' biophysical properties. Accumulating evidence indicates that these subunits may also have roles in the nervous system that are not directly linked to calcium channel function. For example, β subunits may act as transcriptional regulators, and certain α(2)δ subunits may function in synaptogenesis. The aim of this Review is to examine both the classic and novel roles for these auxiliary subunits in voltage-gated calcium channel function and beyond.
Similar articles
-
The alpha2delta subunits of voltage-gated calcium channels form GPI-anchored proteins, a posttranslational modification essential for function.Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1654-9. doi: 10.1073/pnas.0908735107. Epub 2010 Jan 4. Proc Natl Acad Sci U S A. 2010. PMID: 20080692 Free PMC article.
-
Active Zone Trafficking of CaV2/UNC-2 Channels Is Independent of β/CCB-1 and α2δ/UNC-36 Subunits.J Neurosci. 2023 Jul 12;43(28):5142-5157. doi: 10.1523/JNEUROSCI.2264-22.2023. Epub 2023 May 9. J Neurosci. 2023. PMID: 37160370 Free PMC article.
-
Kinetics of internalization and degradation of N-type voltage-gated calcium channels: role of the alpha2/delta subunit.Cell Calcium. 2007 Jan;41(1):27-40. doi: 10.1016/j.ceca.2006.04.010. Epub 2006 Jun 8. Cell Calcium. 2007. PMID: 16759698
-
Voltage-gated calcium channel α 2δ subunits: an assessment of proposed novel roles.F1000Res. 2018 Nov 21;7:F1000 Faculty Rev-1830. doi: 10.12688/f1000research.16104.1. eCollection 2018. F1000Res. 2018. PMID: 30519455 Free PMC article. Review.
-
Emerging roles for α2δ subunits in calcium channel function and synaptic connectivity.Curr Opin Neurobiol. 2020 Aug;63:162-169. doi: 10.1016/j.conb.2020.04.007. Epub 2020 Jun 7. Curr Opin Neurobiol. 2020. PMID: 32521436 Free PMC article. Review.
Cited by
-
Methamphetamine blunts Ca(2+) currents and excitatory synaptic transmission through D1/5 receptor-mediated mechanisms in the mouse medial prefrontal cortex.Addict Biol. 2016 May;21(3):589-602. doi: 10.1111/adb.12249. Epub 2015 Apr 14. Addict Biol. 2016. PMID: 25871318 Free PMC article.
-
Rebuilding essential active zone functions within a synapse.Neuron. 2022 May 4;110(9):1498-1515.e8. doi: 10.1016/j.neuron.2022.01.026. Epub 2022 Feb 16. Neuron. 2022. PMID: 35176221 Free PMC article.
-
The α2δ-1-NMDA receptor coupling is essential for corticostriatal long-term potentiation and is involved in learning and memory.J Biol Chem. 2018 Dec 14;293(50):19354-19364. doi: 10.1074/jbc.RA118.003977. Epub 2018 Oct 24. J Biol Chem. 2018. PMID: 30355732 Free PMC article.
-
Pregabalin for chemotherapy-induced neuropathy: background and rationale for further study.Support Care Cancer. 2022 Nov;30(11):8845-8853. doi: 10.1007/s00520-022-07317-7. Epub 2022 Aug 11. Support Care Cancer. 2022. PMID: 35953729 Review.
-
MicroRNA-423-5p Mediates Cocaine-Induced Smooth Muscle Cell Contraction by Targeting Cacna2d2.Int J Mol Sci. 2023 Apr 1;24(7):6584. doi: 10.3390/ijms24076584. Int J Mol Sci. 2023. PMID: 37047559 Free PMC article.
References
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
