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. 2012 Aug;46(2):174-80.
doi: 10.1002/mus.23296.

Myasthenia gravis: sleep quality, quality of life, and disease severity

Elena Hernández Martínez-Lapiscina  1 , María Elena Erro, Teresa Ayuso, Ivonne Jericó
Affiliations

Myasthenia gravis: sleep quality, quality of life, and disease severity

Elena Hernández Martínez-Lapiscina et al. Muscle Nerve. 2012 Aug.

Erratum in

  • Muscle Nerve. 2014 Jun;49(6):934. Martínez De Lapiscina, Elena Hernández [corrected to Martínez-Lapiscina, Elena Hernández]; Erro Aguirre, María Elena [corrected to Erro, María Elena]; Ayuso Blanco, Teresa [corrected to Ayuso, Teresa]; Jericó Pascual, Ivonne [corrected to Jericó, I

Abstract

Introduction: There is much research on quality of life in myasthenia gravis (MG), and its relationship to disease severity is well-established. However, evidence regarding sleep disturbance in MG is inconclusive.

Methods: To evaluate sleep and quality of life among clinically stable MG patients, 54 subjects were investigated by means of the Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS) and 15-Item-Quality-Of-Life Instrument for MG (MG-QOL15).

Results: A pathological PSQI score, which was observed in 59% of patients, was increased in subjects with active disease compared with patients in clinical remission [odds ratio = 4.3; confidence interval 95% (1.0-17.6); P = 0.04]. We found a relationship between PSQI and MG-QOL15 scores in patients with clinically active disease (r = 0.62; P < 0.001).

Conclusions: Our study highlights the high prevalence of sleep disturbance among MG patients. Disease severity may be considered to be a MG-specific risk factor for patient-reported sleep disturbance. The MG-QOL15 and PSQI should be used to estimate the impact of the disease on sleep and quality of life.

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