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. 2012 Dec;71(10):869-73.
doi: 10.1007/s00393-011-0927-y.

[Local and systemic bone effects of rheumatoid arthritis]

[Article in German]
M Rauner  1 , L C Hofbauer, M Aringer
Affiliations

[Local and systemic bone effects of rheumatoid arthritis]

[Article in German]
M Rauner et al. Z Rheumatol. 2012 Dec.

Abstract

Rheumatoid arthritis (RA) is a bone-destructive disease that is a serious risk factor for the development of osteoporosis, which is defined by a loss in bone quality and an increased fracture risk. The proinflammatory cytokines tumor necrosis factor-α (TNFα), interleukin-6 (IL-6) and IL-17, in particular, contribute to local and systemic bone loss in RA. While effectively reducing inflammation, glucocorticoids add to the fracture risk. Therefore, an adequate supply of calcium and vitamin D is essential. For many patients with RA, bone density measurements are recommended.

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