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. 1979 Nov;32(2):420-8.
doi: 10.1128/JVI.32.2.420-428.1979.

Persistent vesicular stomatitis virus infection mediates base substitutions in viral RNA termini

B L Semler, J J Holland

Persistent vesicular stomatitis virus infection mediates base substitutions in viral RNA termini

B L Semler et al. J Virol. 1979 Nov.

Abstract

We have sequenced (via a product RNA) the 3' RNA terminus of a defective interfering particle that was generated from the standard virus isolated from a culture of BHK-21 cells persistently infected with vesicular stomatitis virus for over 5 years. By hybridization and RNA sequencing, seven mutations were identified in the 46 nucleotides at the terminus of this defective-interfering-particle RNA. It is likely that these mutations are a reflection of altered protein-nucleic acid interactions that the virus has evolved to maintain its persistently infected carrier state in vitro.

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