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. 2012 Sep 3;51(36):9010-4.
doi: 10.1002/anie.201202937. Epub 2012 Jul 13.

A metal-based inhibitor of tumor necrosis factor-α

Chung-Hang Leung  1 , Hai-Jing Zhong, Hui Yang, Zhen Cheng, Daniel Shiu-Hin Chan, Victor Pui-Yan Ma, Ruben Abagyan, Chun-Yuen Wong, Dik-Lung Ma
Affiliations

A metal-based inhibitor of tumor necrosis factor-α

Chung-Hang Leung et al. Angew Chem Int Ed Engl. .

Abstract

Staying in the pocket: A cyclometalated iridium(III) biquinoline complex targets the protein-protein interface (see picture; C yellow, N blue, Ir dark green) of the tumor necrosis factor-α (TNF-α) trimer. Molecular-modeling studies confirm the nature of this interaction. Both enantiomers of the iridium complex display comparable in vitro potency to the strongest small-molecule inhibitor of TNF-α.

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