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. 2012;8(7):e1002775.
doi: 10.1371/journal.ppat.1002775. Epub 2012 Jul 12.

Gastrointestinal cell mediated immunity and the microsporidia

Magali M Moretto  1 , Imtiaz A Khan, Louis M Weiss
Affiliations

Gastrointestinal cell mediated immunity and the microsporidia

Magali M Moretto et al. PLoS Pathog. 2012.
No abstract available

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Putative model of the development of antigen-specific IEL response in the gut after infection with microsporidia.
Once the infecting microsporidia cross the gut intestinal barrier, they are picked up by dendritic cells (DC) either in the Peyer's patch or the lamina propria. These DC become activated, express CCR7, and then migrate to the Mesenteric Lymph Nodes (MLN), where they encounter naïve CD8+ T cells. After antigen presentation, these CD8+ T cells become activated and now express different homing and chemokine receptors that allow them to traffic back to the gut mucosa, where they disseminate throughout the intestinal epithelium, becoming TCRαβIEL and TCRγδIEL.
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