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. 2012 Jul 1;68(Pt 7):o2008-9.
doi: 10.1107/S1600536812023781. Epub 2012 Jun 13.

rac-2-[(2-Chloro-phen-yl)(4-chloro-phen-yl)meth-yl]-1,3-dioxolane

Daniela F Maluf, Sailer S Dos Santos, Claudia C Gatto, Brás H de Oliveira

rac-2-[(2-Chloro-phen-yl)(4-chloro-phen-yl)meth-yl]-1,3-dioxolane

Daniela F Maluf et al. Acta Crystallogr Sect E Struct Rep Online. .

Abstract

The title compound, C(16)H(14)Cl(2)O(2), is a chiral mitotane derivative that contains a dioxolane ring and crystallizes from methanol as a racemic mixture. It was obtained in high yield from mitotane and ethyl-eneglycol in alkaline medium, followed by neutralization with sulfuric acid and extraction with ethyl acetate. The mol-ecular structure is stabilized by an intra-molecular C- H⋯ O hydrogen bond. The dihedral angle between the aromatic rings is 80.1 (2)°. The dioxolane ring adopts a puckered envelope conformation with an O atom as the flap.

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Figures

Fig. 1.
Fig. 1.
The molecular structure of the title compound, with atom labels and 30% probability displacement ellipsoids for non-H atoms.
See this image and copyright information in PMC

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