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. 2012 Jul;23(3):175-81.
doi: 10.3802/jgo.2012.23.3.175. Epub 2012 Jul 2.

Combined panel of serum human tissue kallikreins and CA-125 for the detection of epithelial ovarian cancer

Stephen Chee Liang Koh  1 , Chan Yiong Huak, Delfi Lutan, Johny Marpuang, Suwiyoga Ketut, Nyoma Gede Budiana, Agustria Zainu Saleh, Mohamad Farid Aziz, Hariyono Winarto, Heru Pradjatmo, Nguyen Khac Han Hoan, Pham Viet Thanh, Mahesh Choolani
Affiliations

Combined panel of serum human tissue kallikreins and CA-125 for the detection of epithelial ovarian cancer

Stephen Chee Liang Koh et al. J Gynecol Oncol. 2012 Jul.

Abstract

Objective: To determine the predictive accuracy of the combined panels of serum human tissue kallikreins (hKs) and CA-125 for the detection of epithelial ovarian cancer.

Methods: Serum specimens collected from 5 Indonesian centers and 1 Vietnamese center were analyzed for CA-125, hK6, and hK10 levels. A total of 375 specimens from patients presenting with ovarian tumors, which include 156 benign cysts, 172 epithelial ovarian cancers (stage I/II, n=72; stage III/IV, n=100), 36 germ cell tumors and 11 borderline tumors, were included in the study analysis. Receiver operating characteristic analysis were performed to determine the cutoffs for age, CA-125, hK6, and hK10. Sensitivity, specificity, negative, and positive predictive values were determined for various combinations of the biomarkers.

Results: The levels of hK6 and hK10 were significantly elevated in ovarian cancer cases compared to benign cysts. Combination of 3 markers, age/CA-125/hk6 or CA-125/hk6/hk10, showed improved specificity (100%) and positive predictive value (100%) for prediction of ovarian cancer, when compared to the performance of single markers having 80-92% specificity and 74-87% positive predictive value. Four-marker combination, age/CA-125/hK6/hK10 also showed 100% specificity and 100% positive predictive value, although it demonstrated low sensitivity (11.9%) and negative predictive value (52.8%).

Conclusion: The combination of human tissue kallikreins and CA-125 showed potential for improving prediction of epithelial ovarian cancer in patients presenting with ovarian tumors.

Keywords: Age; Epithelial ovarian cancer; Tumor markers.

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Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1
Fig. 1
Scatter plots with mean levels indicated comparing the variable distribution of age, CA-125, human tissue kallikrein 6 (hK6), hK10 between benign cyst and ovarian cancer stage I/II and stage III/IV.
See this image and copyright information in PMC

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