Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1990 Nov 13;119(2):207-10.
doi: 10.1016/0304-3940(90)90835-w.

Cholinergic stimulation enhances long-term potentiation in the CA1 region of rat hippocampus

R D Blitzer  1 , O Gil, E M Landau
Affiliations
Comparative Study

Cholinergic stimulation enhances long-term potentiation in the CA1 region of rat hippocampus

R D Blitzer et al. Neurosci Lett. .

Abstract

The effect of the cholinergic agonist carbachol on a putative substrate for memory (long-term potentiation; LTP) was investigated in slices of rat hippocampus (CA1 region). Carbachol (5 microM) increased LTP when the presynaptic depression of the EPSP was controlled. The results indicate that carbachol enhances the effectiveness of the tetanus, probably through postsynaptic mechanisms. This effect may have implications for the role of acetylcholine in memory and the use of cholinergics in memory disorders.

PubMed Disclaimer

Publication types

LinkOut - more resources