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Editorial
. 2012 Jul 19;14(4):122.
doi: 10.1186/ar3891.

Inflammation, endothelial function and atherosclerosis in rheumatoid arthritis

Miguel A González-Gay, Carlos González-Juanatey
Editorial

Inflammation, endothelial function and atherosclerosis in rheumatoid arthritis

Miguel A González-Gay et al. Arthritis Res Ther. .

Abstract

Different techniques have proven to be useful in determining the presence of subclinical cardiovascular disease in patients with rheumatoid arthritis (RA). Doppler imaging with iontophoresis of acetylcholine and flow-mediated, endothelium-dependent vasodilation give information on endothelial dysfunction, an early step in the atherogenesis process. However, there is no good correlation between these two surrogate markers of cardiovascular disease in RA. A single determination of routine laboratory markers of inflammation does not seem to relate to endothelial function in RA. Further research is needed to determine whether microvascular endothelial function is a better predictor of cardiovascular outcome than macrovascular endothelial function in patients with RA.

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References

    1. Sandoo A, Kitas GD, Carroll D, Veldhuijzen van Zanten JJCS. The role of inflammation and cardiovascular disease risk on microvascular and macrovascular endothelial function in patients with rheumatoid arthritis: a crosssectional and longitudinal study. Arthritis Res Ther. 2012;14:R117. doi: 10.1186/ar3847. - DOI - PMC - PubMed
    1. Gonzalez-Gay MA, Gonzalez-Juanatey C, Martin J. Rheumatoid arthritis: a disease associated with accelerated atherogenesis. Semin Arthritis Rheum. 2005;35:8–17. doi: 10.1016/j.semarthrit.2005.03.004. - DOI - PubMed
    1. Kerekes G, Soltész P, Nurmohamed MT, Gonzalez-Gay MA, Turiel M, Végh E, Shoenfeld Y, McInnes I, Szekanecz Z. Validated methods for assessment of subclinical atherosclerosis in rheumatology. Nat Rev Rheumatol. 2012;8:224–234. doi: 10.1038/nrrheum.2012.16. - DOI - PubMed
    1. Gonzalez-Gay MA, Gonzalez-Juanatey C, Piñeiro A, Garcia-Porrua C, Testa A, Llorca J. High-grade C-reactive protein elevation correlates with accelerated atherogenesis in patients with rheumatoid arthritis. J Rheumatol. 2005;32:1219–1223. - PubMed
    1. González-Juanatey C, Llorca J, González-Gay MA. Correlation between endothelial function and carotid atherosclerosis in rheumatoid arthritis patients with long-standing disease. Arthritis Res Ther. 2011;13:R101. doi: 10.1186/ar3382. - DOI - PMC - PubMed

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