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Review
. 2012 Jul 19;16(4):316.
doi: 10.1186/cc11252.

Vitamin D in sepsis: from basic science to clinical impact

Jordan A Kempker, Vin Tangpricha, Thomas R Ziegler, Greg S Martin
Review

Vitamin D in sepsis: from basic science to clinical impact

Jordan A Kempker et al. Crit Care. .

Abstract

The growing basic and clinical investigations into the extraskeletal effects of vitamin D have revealed roles in the functioning of the immune system, generating interesting questions about this nutrient's connections to sepsis. This article briefly reviews the current science of the function of vitamin D in the immune system as well as the emerging clinical literature regarding its associations with respiratory infections, sepsis, and critical illness. Finally, we offer views on the potential future directions for research in the field by outlining potential relevant scenarios and outcomes.

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References

    1. Wang TT, Tavera-Mendoza LE, Laperriere D, Libby E, MacLeod NB, Nagai Y, Bourdeau V, Konstorum A, Lallemant B, Zhang R, Mader S, White JH. Largescale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005;19:2685–2695. doi: 10.1210/me.2005-0106. - DOI - PubMed
    1. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96:1911–1930. doi: 10.1210/jc.2011-0385. - DOI - PubMed
    1. Yamshchikov AV, Desai NS, Blumberg HM, Ziegler TR, Tangpricha V. Vitamin D for treatment and prevention of infectious diseases: a systematic review of randomized controlled trials. Endocr Pract. 2009;15:438–449. doi: 10.4158/EP09101.ORR. - DOI - PMC - PubMed
    1. Sokol SI, Tsang P, Aggarwal V, Melamed ML, Srinivas VS. Vitamin D status and risk of cardiovascular events: lessons learned via systematic review and meta-analysis. Cardiol Rev. 2011;19:192–201. doi: 10.1097/CRD.0b013e31821da9a5. - DOI - PubMed
    1. Zhao G, Ford ES, Li C, Croft JB. Serum 25-hydroxyvitamin D levels and allcause and cardiovascular disease mortality among US adults with hypertension: the NHANES linked mortality study. J Hypertens. 2012;30:284–289. doi: 10.1097/HJH.0b013e32834e1f0a. - DOI - PubMed

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