Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2012 Jul 19;13(8):719-20.
doi: 10.1038/ni.2377.

Negative regulators take center stage

Silvia Monticelli  1 , Federica Sallusto
Affiliations
Comment

Negative regulators take center stage

Silvia Monticelli et al. Nat Immunol. .

Abstract

The transcription factor Aiolos is upregulated in T lymphocytes in a manner dependent on the transcription factors STAT3 and AhR and leads to epigenetic silencing of the gene encoding interleukin 2. This acts as a cell-intrinsic safeguard mechanism for the differentiation of helper T cells into the TH17 subset.

PubMed Disclaimer

Comment on

References

    1. Nat Immunol. 2011 Mar;12(3):247-54 - PubMed
    1. Nat Immunol. 2012 Jul 01;13(8):770-7 - PubMed
    1. Nat Immunol. 2003 Jul;4(7):616-23 - PubMed
    1. Science. 2009 Aug 28;325(5944):1142-6 - PubMed
    1. Nat Rev Immunol. 2011 Apr;11(4):239-50 - PubMed

LinkOut - more resources