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. 2012 Jul 17;23(1):7-8.
doi: 10.1016/j.devcel.2012.06.009.

Calcineurin/NFATc signaling: role in postnatal β cell development and diabetes mellitus

Martin Kragl  1 , Eckhard Lammert
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Calcineurin/NFATc signaling: role in postnatal β cell development and diabetes mellitus

Martin Kragl et al. Dev Cell. .
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Abstract

Pancreatic islets are aggregates of endocrine cells required for blood glucose control and diabetes prevention after birth. In this issue of Developmental Cell, Goodyer et al. (2012) reveal a function of calcineurin, a calcium-activated serine/threonine phosphatase, in postnatal NFATc-regulated expression of genes that help β cells to form insulin-containing vesicles and enter the cell cycle.

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