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. 2012 Jun;7(6):705-8.

Two antiproliferative saponins of Tarenna grevei from the Madagascar dry forest [1]

Liva Harinantenaina  1 , Peggy J Brodie, Martin W Callmander, L Jérémie Razafitsalama, Vincent E Rasamison, Etienne Rakotobe, David G I Kingston
Affiliations

Two antiproliferative saponins of Tarenna grevei from the Madagascar dry forest [1]

Liva Harinantenaina et al. Nat Prod Commun. 2012 Jun.

Abstract

Antiproliferative bioassay-guided fractionation of the ethanol extract of the endemic Malagasy Rubiaceous plant Tarenna grevei led to the isolation of two new antiproliferative oxygenated oleanane triterpene saponins. The structures of the two active compounds were elucidated as 23-hydroxylongispinogenin 3-O-beta-D-glucopyranoside (1) and longispinogenin 3-O-beta-D-glucopyranosyl (1 --> 2)-beta-D-glucopyranoside (3) by analyses of their spectral data including 1D- and 2D-NMR spectroscopy and chemical evidence. Compounds 1 and 3 displayed moderate antiproliferative activity against the A2780 ovarian cancer cell line with IC50 values of 7.6 and 4 microM, respectively.

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Figures

Figure 1
Figure 1
Important HMBC correlations observed in 1.
Figure 2
Figure 2
Structures of compounds 1–2.
Figure 3
Figure 3
Structures of compounds 3–4.
See this image and copyright information in PMC

References

    1. Biodiversity conservation and drug discovery in Madagascar, Part 51. For Part 50, see Dai Y, Harinantenaina L, Brodie PJ, Callmander MW, Randrianaivo R, Rakotonandrasana S, Rakotobe E, Rasamison VE, Shen Y, TenDyke K, Suh EM, Kingston DGI. Antiproliferative acetogenins from a Uvaria sp. from the Madagascar dry forest. Journal of Natural Products. 2012 in press.

    1. Mabberley DJ. The Plant-Book. A Portable Dictionary of the Higher Plants. Cambridge, England: Cambridge University Press; 1997.
    1. Zhao Z, Matsunami K, Otsuka H, Shinzato T, Takeda Y. Tareciliosides H-M: Further cycloartane glycosides from leaves of Tarenna gracilipes. Chemical and Pharmaceutical Bulletin. 2011;59:902–905. - PubMed
    1. Zhao Z, Matsunami K, Otsuka H, Shinzato T, Takeda Y. Tareciliosides A-G: Cycloartane glycosides from leaves of Tarenna gracilipes. Chemical and Pharmaceutical Bulletin. 2008;56:1153–1158. - PubMed
    1. Yang X-W, Zhao P-J, Ma Y-L, Xiao H-T, Zuo Y-Q, He H-P, Li L, Hao X-J. Mixed lignan-neolignans from Tarenna attenuata. Journal of Natural Products. 2007;70:521–525. - PubMed

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