doi: 10.1007/BF00501394.
Indirect evidence for presynaptic location of opiate receptors on chemosensitive primary sensory neurones
- PMID: 228212
- DOI: 10.1007/BF00501394
Item in Clipboard
Indirect evidence for presynaptic location of opiate receptors on chemosensitive primary sensory neurones
Naunyn Schmiedebergs Arch Pharmacol.
1979 Sep.
Abstract
1. Rats were pretreated with 50 mg/kg s.c. capsaicin or solvent on the second day of life; 5 months later 3H-diprenorphine binding to homogenates of the whole spinal cord or of the upper dorsal horn of the spinal cord was investigated. 2. Capsaicin pretreatment resulted in a 17% decrease of opiate binding sites in the whole spinal cord and a 37% decrease in the upper dorsal horn with no change in their affinity. 3. Since neonatal capsaicin pretreatment causes degeneration of chemosensitive primary sensory neurones it is concluded that some opiate receptors are located presynaptically on the central terminals of these neurones.
Similar articles
-
5-HT3 receptor binding sites are on capsaicin-sensitive fibres in the rat spinal cord.Eur J Pharmacol. 1989 May 19;164(2):315-22. doi: 10.1016/0014-2999(89)90472-x. Eur J Pharmacol. 1989. PMID: 2759179
-
Characterization of kappa opiate receptors in rat spinal cord-dorsal root ganglion cocultures and their regulation by chronic opiate treatment.Brain Res. 1990 May 28;517(1-2):182-8. doi: 10.1016/0006-8993(90)91024-b. Brain Res. 1990. PMID: 2165432
-
Effect of transganglionic degenerative atrophy on opiate receptors in the dorsal horn of the spinal cord.J Neurosci Res. 1982;8(4):665-70. doi: 10.1002/jnr.490080411. J Neurosci Res. 1982. PMID: 6298441
-
Neurotoxic effect of capsaicin in mammals.Acta Physiol Hung. 1987;69(3-4):295-313. Acta Physiol Hung. 1987. PMID: 3310520 Review.
-
Opiate receptor multiplicity: evidence for multiple mu receptors.Monogr Neural Sci. 1987;13:121-31. doi: 10.1159/000414573. Monogr Neural Sci. 1987. PMID: 2825002 Review. No abstract available.
Cited by
-
Pain and Poppies: The Good, the Bad, and the Ugly of Opioid Analgesics.J Neurosci. 2015 Oct 14;35(41):13879-88. doi: 10.1523/JNEUROSCI.2711-15.2015. J Neurosci. 2015. PMID: 26468188 Free PMC article. Review.
-
Resistance to morphine analgesic tolerance in rats with deleted transient receptor potential vanilloid type 1-expressing sensory neurons.Neuroscience. 2007 Mar 16;145(2):676-85. doi: 10.1016/j.neuroscience.2006.12.016. Epub 2007 Jan 17. Neuroscience. 2007. PMID: 17239544 Free PMC article.
-
Alstonia scholaris R. Br. Significantly Inhibits Retinoid-Induced Skin Irritation In Vitro and In Vivo.Evid Based Complement Alternat Med. 2012;2012:190370. doi: 10.1155/2012/190370. Epub 2011 Sep 8. Evid Based Complement Alternat Med. 2012. PMID: 21912567 Free PMC article.
-
beta-Endorphin: characteristics of binding sites in rabbit spinal cord.Proc Natl Acad Sci U S A. 1980 Oct;77(10):5746-8. doi: 10.1073/pnas.77.10.5746. Proc Natl Acad Sci U S A. 1980. PMID: 6255463 Free PMC article.
-
Side Effects of Opioids Are Ameliorated by Regulating TRPV1 Receptors.Int J Environ Res Public Health. 2022 Feb 18;19(4):2387. doi: 10.3390/ijerph19042387. Int J Environ Res Public Health. 2022. PMID: 35206575 Free PMC article. Review.