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Case Reports
. 2012 Oct;34(5):690-2.
doi: 10.1007/s11096-012-9653-z. Epub 2012 Jul 21.

Overdose of pegfilgrastim: case report

Gisela Riu  1 , Anna Estefanell, Meritxell Nomdedeu, Natàlia Creus
Affiliations
Case Reports

Overdose of pegfilgrastim: case report

Gisela Riu et al. Int J Clin Pharm. 2012 Oct.

Abstract

Background: Pegfilgrastim is a G-CSF that can be administered in a single dose 24 h after each cycle of chemotherapy.

Case: 59 years-old man with a stage III-B peripheral T lymphoma with CD4 expression. Dose-dense chemotherapy was started with CHOP-14 combined with pegfilgrastim as primary prophylaxis. An error in the dispensing system meant that the patient received pegfilgrastim for 4 consecutive days. He remained under observation in hospital. During the 3 days after the last dose of pegfilgrastim, the patient remained stable, with no remarkable symptoms or associated laboratory abnormalities, and was discharged.

Conclusion: The case we describe and the available literature lead us to suggest close monitoring as the main measure to be adopted when treating a patient for pegfilgrastim overdose.

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