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. 2012 Jul 8;68(27-28):5422-5428.
doi: 10.1016/j.tet.2012.04.101. Epub 2012 May 5.

Application of Chemoenzymatic Hydrolysis in the Synthesis of 2-Monoacylglycerols

Kyle M Whitten  1 , Alexandros Makriyannis, Subramanian K Vadivel
Affiliations

Application of Chemoenzymatic Hydrolysis in the Synthesis of 2-Monoacylglycerols

Kyle M Whitten et al. Tetrahedron. .

Abstract

The selective biocatalyzed synthesis of 2-monoacylglycerols (2-MAGs) through the use of commercially available immobilized Candida antarctica (Novozym435) and Rhizomucor miehei is explored. Reactions at room temperature result in the formation of a 2-MAG and a corresponding ethyl ester of the fatty acid with immobilized Candida antarctica within 2h with yields ranging from 36%-83%. Similar reaction conditions with immobilized Rhizomucor miehei yielded exclusively the 2-MAG after 24h with yields ranging from 37% to 88%. Yields vary on the acyl group at the sn-2 position and choice of enzyme involved.

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