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Review
. 2012 Aug;16(3):487-504.
doi: 10.1016/j.cld.2012.05.006. Epub 2012 Jun 27.

The relevance of liver histology to predicting clinically meaningful outcomes in nonalcoholic steatohepatitis

Mangesh R Pagadala  1 , Arthur J McCullough
Affiliations
Review

The relevance of liver histology to predicting clinically meaningful outcomes in nonalcoholic steatohepatitis

Mangesh R Pagadala et al. Clin Liver Dis. 2012 Aug.

Abstract

Nonalcoholic fatty liver disease (NAFLD) has emerged as the most prevalent chronic liver disease. Nonalcoholic steatohepatitis (NASH), the more severe form of NAFLD, has an increased risk for progression to cirrhosis. The available data suggest increased morbidity and mortality among those patients with advanced histologic severity such as NASH and fibrosis. Despite the lack of a universally accepted histologic definition of NAFLD and inconsistency among pathologists regarding histologic findings essential to the diagnosis of NASH, a few studies have identified specific histologic findings (particularly fibrosis regardless of stage) that are able to predict NAFLD-related mortality as being most important.

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Figures

Figure. 1
Figure. 1
The spectrum and the natural progression of nonalcoholic fatty liver disease
See this image and copyright information in PMC

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