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Randomized Controlled Trial
. 2012 Jul;60(4):273-6.
doi: 10.4103/0301-4738.98703.

Efficacy of preoperative injection versus intraoperative application of mitomycin in recurrent pterygium surgery

Khaled S Zaky  1 , Yasser M Khalifa
Affiliations
Randomized Controlled Trial

Efficacy of preoperative injection versus intraoperative application of mitomycin in recurrent pterygium surgery

Khaled S Zaky et al. Indian J Ophthalmol. 2012 Jul.

Abstract

Purpose: To determine the efficacy of preoperative subconjunctival injection of mitomycin C a day before surgery in the management of recurrent pterygium.

Materials and methods: Randomized comparative case series. Fifty eyes with recurrent pterygium were randomly divided into two groups; the mitomycin injection group (25 eyes) and the mitomycin application group (25 eyes). The mitomycin injection group underwent preoperative subconjunctival injection of mitomycin C in low dose (0.1 ml of 0.15 mg/ml) a day before bare sclera pterygium excision surgery. The mitomycin application group underwent bare sclera pterygium excision with topical application of mitomycin C (same concentration).

Results: At one year of follow-up, 24 of 25 eyes (96%) in the mitomycin injection group and 23 of 25 (92%) eyes in the mitomycin application group were free of recurrence. The difference was statistically insignificant. As regards postoperative complications, delayed epithelization (more than two weeks) occurred in two eyes (8%) in the mitomycin injection group and in one eye (4%) in the mitomycin application group. Scleral thinning was reported in one eye (4%) in the mitomycin application group which resolved within three weeks after surgery, no other serious postoperative complications were reported.

Conclusion: Preoperative subconjunctival injection of mitomycin C in low dose (0.1 ml of 0.15 mg/ml) a day before pterygium surgery is a simple and effective modality for management of recurrent pterygium. It has the advantage of low recurrence and complications' rate.

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Conflict of interest statement

Conflict of Interest: None declared.

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