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Case Reports
. 2012 Aug;120(2 Pt 2):480-483.
doi: 10.1097/AOG.0b013e31825935d4.

Pregnancy outcome in anti-N-methyl-D-aspartate receptor encephalitis

Joseph Magley  1 , Dena Towner, Véronique Taché, Michelle L Apperson
Affiliations
Case Reports

Pregnancy outcome in anti-N-methyl-D-aspartate receptor encephalitis

Joseph Magley et al. Obstet Gynecol. 2012 Aug.

Abstract

Background: Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis is an autoimmune disorder resulting in neurologic and psychiatric symptoms. Treatment is challenging in pregnancy, because little data exist to guide management.

Case: A 24-year-old woman with a known diagnosis of anti-NMDA receptor encephalitis using intravenous immunoglobulin therapy became pregnant. Her pregnancy was uncomplicated with no relapses. She delivered at 35 4/7 weeks of gestation after having preterm premature rupture of membranes. She had a relapse of symptoms after delivery.

Conclusion: This patient with anti-NMDA receptor encephalitis had an uneventful pregnancy with overall good outcome; however, she experienced relapse soon after delivery. This disease may mimic other autoimmune diseases, with improvement during pregnancy and risk for relapse postpartum.

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References

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