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. 2012 Sep;84(9):1459-63.
doi: 10.1002/jmv.23319.

Dynamics of urinary polyomavirus shedding in healthy adult women

Courtney L Kling  1 , Alexandra T Wright, Sophie E Katz, Gloria B McClure, J Suzette Gardner, Jason T Williams, Natalie M Meinerz, Robert L Garcea, John A Vanchiere
Affiliations

Dynamics of urinary polyomavirus shedding in healthy adult women

Courtney L Kling et al. J Med Virol. 2012 Sep.

Abstract

The hypothesis was examined that physiologic variation of estrogen concentrations during the menstrual cycle can provoke BK virus (BKV) excretion. BKV and JCV viral loads were determined in urine specimens obtained almost daily from 20 healthy, non-pregnant women over 2 months. Asymptomatic urinary shedding of BKV was observed in 123 (12.0%) of 1,021 specimens from 11 (55%) study subjects. Two subjects excreted JCV in their urine, with one subject excreting detectable JCV in all urine specimens. Analysis of 36 complete menstrual cycles revealed no difference in the prevalence of BKV excretion between pre-ovulatory and post-ovulatory phases of the menstrual cycle. The unexpected day-to-day variability in BKV excretion suggests that as yet unidentified factors may contribute to the periodic shedding of BKV by healthy women.

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Conflict of interest statement

The authors have no commercial or other association that might pose a conflict of interest related to this study or its publication.

Figures

Fig. 1
Fig. 1
Polyomavirus excretion by selected subjects, relative to ovulation and menses. A, B: BKV excretion by subjects M115 and M108, respectively; (C) JCV excretion by subject M105. Undetectable virus is plotted as 0. [Color figure can be seen in the online version of this article, available at http://wileyonlinelibrary.com/journal/jmv]
See this image and copyright information in PMC

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