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Comment
. 2012 Jul 31;109(31):12270-1.
doi: 10.1073/pnas.1209749109. Epub 2012 Jul 23.

IL-7 receptor α blockade, an off-switch for autoreactive T cells

Tobias Boettler  1 , Matthias von Herrath
Affiliations
Comment

IL-7 receptor α blockade, an off-switch for autoreactive T cells

Tobias Boettler et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
IL-7 and PD-1 have antagonistic effects in the regulation of immune responses. PD-1 expression is diminished in the presence of high IL-7 levels, causing improved T cell-mediated immune control of tumor and viruses (7, 8) but enhancing the risk for development of autoimmune diseases (9, 10). In contrast, blockade of IL-7 signaling increases PD-1 expression, thus protecting the host from autoimmune diseases (2, 3). Whether or not this setting bears the risk for development of opportunistic infections or cancer requires careful investigation.
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References

    1. Bluestone JA, Herold K, Eisenbarth G. Genetics, pathogenesis and clinical interventions in type 1 diabetes. Nature. 2010;464:1293–1300. - PMC - PubMed
    1. Lee L-F, et al. Anti–IL-7 receptor-α reverses established type 1 diabetes in nonobese diabetic mice by modulating effector T-cell function. Proc Natl Acad Sci USA. 2012;109:12674–12679. - PMC - PubMed
    1. Penaranda C, et al. IL-7 receptor blockade reverses autoimmune diabetes by promoting inhibition of effector/memory T cells. Proc Natl Acad Sci USA. 2012;109:12668–12673. - PMC - PubMed
    1. Schluns KS, Kieper WC, Jameson SC, Lefrançois L. Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo. Nat Immunol. 2000;1:426–432. - PubMed
    1. Nanjappa SG, Walent JH, Morre M, Suresh M. Effects of IL-7 on memory CD8 T cell homeostasis are influenced by the timing of therapy in mice. J Clin Invest. 2008;118:1027–1039. - PMC - PubMed