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Comment
. 2012 Jul 31;109(31):12270-1.
doi: 10.1073/pnas.1209749109. Epub 2012 Jul 23.

IL-7 receptor α blockade, an off-switch for autoreactive T cells

Tobias Boettler  1 , Matthias von Herrath
Affiliations
Comment

IL-7 receptor α blockade, an off-switch for autoreactive T cells

Tobias Boettler et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
IL-7 and PD-1 have antagonistic effects in the regulation of immune responses. PD-1 expression is diminished in the presence of high IL-7 levels, causing improved T cell-mediated immune control of tumor and viruses (7, 8) but enhancing the risk for development of autoimmune diseases (9, 10). In contrast, blockade of IL-7 signaling increases PD-1 expression, thus protecting the host from autoimmune diseases (2, 3). Whether or not this setting bears the risk for development of opportunistic infections or cancer requires careful investigation.
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References

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