Involvement of cell adhesion molecules in the pathogenesis of experimental autoimmune uveoretinitis

Abstract

Cell adhesion molecules (CAMs) are cell surface proteins that are important for the interaction between cells and the extracellular matrix. These CAMs are critical for the migration of leukocytes to areas of inflammation. In addition, CAMs are involved in the interaction of lymphocytes and antigen presenting cells, and play an integral role in lymphocyte stimulation. Experimental autoimmune uveoretinitis (EAU) is an experimental model of posterior uveitis in humans. Recent studies show that CAM expression is upregulated in eyes with EAU. Furthermore, studies have now demonstrated that antibodies against certain CAMs can inhibit EAU. This paper reviews the role of CAMs in EAU.