Fertility-sparing surgery for early-stage cervical cancer
- PMID: 22830004
- PMCID: PMC3399357
- DOI: 10.1155/2012/936534
Fertility-sparing surgery for early-stage cervical cancer
Abstract
Nowadays cervical cancer is diagnosed in many women who still want to have children. This led to the need to provide fertility-sparing treatments. The main goal is to maintain reproductive ability without decreasing overall and recurrence-free survival. In this article, we review data on procedures for fertility preservation, namely, vaginal and abdominal trachelectomy, less invasive surgery and neoadjuvant chemotherapy. For each one, oncological and obstetrical outcomes are analyzed. Comparing to traditionally offered radical hysterectomy, the overall oncologic safety is good, with promising obstetrical outcomes.
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References
-
- Arbyn M, Autier P, Ferlay J. Burden of cervical cancer in the 27 member states of the European Union: estimates for 2004. Annals of Oncology. 2007;18(8):1423–1425. - PubMed
-
- Diaz JP, Sonoda Y, Leitao MM, et al. Oncologic outcome of fertility-sparing radical trachelectomy versus radical hysterectomy for stage IB1 cervical carcinoma. Gynecologic Oncology. 2008;111(2):255–260. - PubMed
-
- Ramirez PT, Schmeler KM, Soliman PT, Frumovitz M. Fertility preservation in patients with early cervical cancer: radical trachelectomy. Gynecologic Oncology. 2008;110(3):S25–S28. - PubMed
-
- Noguchi H, Shiozawa I, Kitahara T, Yamazaki T, Fukuta T. Uterine body invasion of carcinoma of the uterine cervix as seen from surgical specimens. Gynecologic Oncology. 1988;30(2):173–182. - PubMed
-
- Benedetti-Panici P, Maneschi F, D'Andrea G, Cutillo G, Rabitti C, Congiu M. Early cervical carcinoma: the natural history of lymph node involvement redefined on the basis of thorough parametrectomy and giant section study. Cancer. 2000;88:2267–2274. - PubMed
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