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. 2012:2012:108164.
doi: 10.5402/2012/108164. Epub 2012 Jul 8.

Microemulsion drug delivery system: for bioavailability enhancement of ampelopsin

Shailendra Singh Solanki  1 , Brajesh Sarkar, Rakesh Kumar Dhanwani
Affiliations

Microemulsion drug delivery system: for bioavailability enhancement of ampelopsin

Shailendra Singh Solanki et al. ISRN Pharm. 2012.

Abstract

Ampelopsin, one of the most common flavonoids, reported to possess numerous pharmacological activities and shows poor aqueous solubility. The purpose of this study was to enhance the dissolution rate and bioavailability of this drug by developing a novel delivery system that is microemulsion (ME) and to study the effect of microemulsion (ME) on the oral bioavailability of ampelopsin. Capmul MCM-based ME formulation with Cremophor EL as surfactant and Transcutol as cosurfactant was developed for oral delivery of ampelopsin. Optimised ME was evaluated for its transparency, viscosity, percentage assay and so forth. Solubilisation capacity of the ME system was also determined. The prepared ME was compared with the pure drug solution and commercially available tablet for in vitro drug release. The optimised ME formulation containing ampelopsin, Capmul MCM (5.5%), Cremophor EL (25%), Transcutol P (8.5%), and distilled water showed higher in vitro drug release, as compared to plain drug suspension and the suspension of commercially available tablet. These results demonstrate the potential use of ME for improving the bioavailability of poor water soluble compounds, such as ampelopsin.

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Figures

Figure 1
Figure 1
Structure of ampelopsin.
Figure 2
Figure 2
Viscosity changes of ME with increasing water content.
Figure 3
Figure 3
Results of the electroconductivity study.
Figure 4
Figure 4
In vitro drug release of drug from microemulsion (ME), commercially Ampelopsin formulation (CAF), and plain drug suspension (PDS).
See this image and copyright information in PMC

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