doi: 10.1073/pnas.76.9.4658.
Sodium transport inhibitor from bovine hypothalamus
- PMID: 228304
- PMCID: PMC411639
- DOI: 10.1073/pnas.76.9.4658
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Sodium transport inhibitor from bovine hypothalamus
Proc Natl Acad Sci U S A.
1979 Sep.
Abstract
A low molecular weight, basic, nonpeptidic factor that possesses sodium transport inhibitory properties has been prepared from bovine hypothalamus by acid/acetone extraction and gel filtration. Concentration and partial purification was achieved by ion-exchange chromatography. This substance inhibits active Na+ transport across anuran membranes, inhibits ouabain binding to frog urinary bladder, and directly inhibits renal Na+,K+-ATPase. This substance thus possesses the putative characteristics of a natriuretic factor of hypothalamic origin.
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