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. 2012 Dec;44(12):941-7.
doi: 10.3109/00365548.2012.700769. Epub 2012 Jul 25.

Treatment of pandemic influenza A (H1N1) 2009-associated encephalopathy in children

Hisashi Kawashima  1 , Shinichiro Morichi, Akihisa Okumara, Satoshi Nakagawa, Tsuneo Morishima; Collaborating Study Group on Influenza-Associated Encephalopathy in Japan
Affiliations

Treatment of pandemic influenza A (H1N1) 2009-associated encephalopathy in children

Hisashi Kawashima et al. Scand J Infect Dis. 2012 Dec.

Abstract

Background: The novel pandemic influenza A (H1N1) 2009 virus (influenza A(H1N1)pdm09) caused an epidemic of critical illness, with some patients developing fatal encephalopathy as well as pneumonia.

Methods: To investigate the actual efficacy of treatments, we investigated data from questionnaires regarding 207 cases that occurred between September 2009 and February 2010.

Results: The outcomes were recorded in 188 of the 207 cases; 16 of 188 patients died, while 23 had sequelae. Anti-influenza drugs in patients with severe coma (Glasgow coma scale score of ≤ 8) were statistically effective. In 165 out of 199 cases, steroid pulse treatment with methylprednisolone was given at an early stage. Other intensive treatments were mostly administered in serious cases.

Conclusions: Controlled studies are needed to investigate the efficacy of other treatments except for anti-influenza drugs.

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