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. 1979 Sep;76(9):4661-3.
doi: 10.1073/pnas.76.9.4661.

Endogenous digitalis-like activity in mammalian brain

M C Fishman

Endogenous digitalis-like activity in mammalian brain

M C Fishman. Proc Natl Acad Sci U S A. 1979 Sep.

Abstract

A fraction of brain has been prepared that contains a substance mimicking actions of the digitalis glycosides. It both blocks the binding of [3H]ouabain to Na+,K+-ATPase (ATP phosphohydrolase, EC 3.6.1.3) and inhibits the uptake of 86Rb+ into human erythrocytes. Partial isolation was achieved by Sephadex G-10 fractionation and subsequent desalting. This activity is potentially capable of regulating ionic fluxes and concentration gradients across the cell membrane.

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References

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    1. Proc Natl Acad Sci U S A. 1979 Sep;76(9):4658-60 - PubMed
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