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. 1990 Aug;25(1-3):71-6.
doi: 10.1016/0165-2478(90)90094-7.

Non-CS pre-erythrocytic protective antigens

M R Hollingdale  1 , M Aikawa, C T Atkinson, W R Ballou, G X Chen, J Li, J F Meis, B Sina, C Wright, J D Zhu
Affiliations

Non-CS pre-erythrocytic protective antigens

M R Hollingdale et al. Immunol Lett. 1990 Aug.

Abstract

Three novel non-CS antigens have been identified on P. falciparum and P. berghei sporozoites and exoerythrocytic parasites. CSP-2 is a sporozoite surface protein common to P. falciparum and P. berghei that elicits antibody-mediated protection, and is also found within P. berghei EE parasites. LSA is a P. falciparum EE-specific antigen localized within the parasitophorous vacuole. LSA-2 is a P. berghei EE-specific antigen, localized on the parasitophorous vacuole membrane, that protected mice to P. berghei sporozoite challenge, and elicited cytotoxic T cells that killed P. berghei EE parasites in vitro.

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