doi: 10.1016/0165-2478(90)90094-7.
Non-CS pre-erythrocytic protective antigens
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- PMID: 2283163
- DOI: 10.1016/0165-2478(90)90094-7
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Non-CS pre-erythrocytic protective antigens
Immunol Lett.
1990 Aug.
Abstract
Three novel non-CS antigens have been identified on P. falciparum and P. berghei sporozoites and exoerythrocytic parasites. CSP-2 is a sporozoite surface protein common to P. falciparum and P. berghei that elicits antibody-mediated protection, and is also found within P. berghei EE parasites. LSA is a P. falciparum EE-specific antigen localized within the parasitophorous vacuole. LSA-2 is a P. berghei EE-specific antigen, localized on the parasitophorous vacuole membrane, that protected mice to P. berghei sporozoite challenge, and elicited cytotoxic T cells that killed P. berghei EE parasites in vitro.
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