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. 2012 Mar 13;2(3):e92.
doi: 10.1038/tp.2012.18.

The relationship between subtypes of depression and cardiovascular disease: a systematic review of biological models

B T Baune  1 , M Stuart, A Gilmour, H Wersching, W Heindel, V Arolt, K Berger
Affiliations

The relationship between subtypes of depression and cardiovascular disease: a systematic review of biological models

B T Baune et al. Transl Psychiatry. .

Abstract

A compelling association has been observed between cardiovascular disease (CVD) and depression, suggesting individuals with depression to be at significantly higher risk for CVD and CVD-related mortality. Systemic immune activation, hypothalamic-pituitary-adrenal (HPA) axis hyperactivity, arterial stiffness and endothelial dysfunction have been frequently implicated in this relationship. Although a differential epidemiological association between CVD and depression subtypes is evident, it has not been determined if this indicates subtype specific biological mechanisms. A comprehensive systematic literature search was conducted using PubMed and PsycINFO databases yielding 147 articles for this review. A complex pattern of systemic immune activation, endothelial dysfunction and HPA axis hyperactivity is suggestive of the biological relationship between CVD and depression subtypes. The findings of this review suggest that diagnostic subtypes rather than a unifying model of depression should be considered when investigating the bidirectional biological relationship between CVD and depression. The suggested model of a subtype-specific biological relationship between depression and CVDs has implications for future research and possibly for diagnostic and therapeutic processes.

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Figures

Figure 1
Figure 1
Study inclusion flowchart.
Figure 2
Figure 2
Biological mechanisms for the bidirectional relationship between depression and CVD.
See this image and copyright information in PMC

References

    1. Goldston K, Baillie AJ. Depression and coronary heart disease: a review of the epidemiological evidence, explanatory mechanisms and management approaches. Clin Psychol Rev. 2008;28:288–306. - PubMed
    1. Frasure-Smith N, Lesperance F. Depression and cardiac risk: present status and future directions. Heart. 2010;96:173–176. - PubMed
    1. Van der Kooy K, Van Hout H, Marwijk H, Marten H, Stehouwer C, Beekman A. Depression and the risk for cardiovascular diseases: systematic review and meta analysis. Int J Geriatr Psychiatry. 2007;22:613–626. - PubMed
    1. Rudisch B, Nemeroff CB. Epidemiology of comorbid coronary artery disease and depression. Biol Psychiatry. 2003;54:227–240. - PubMed
    1. Grippo AJ, Johnson AK. Biological mechanisms in the relationship between depression and heart disease. Neurosci Biobehav Rev. 2002;26:941–962. - PubMed

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