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. 2012 Jul 20:3:215.
doi: 10.3389/fimmu.2012.00215. eCollection 2012.

Cross-reactive broadly neutralizing antibodies: timing is everything

Zelda Euler  1 , Hanneke Schuitemaker
Affiliations

Cross-reactive broadly neutralizing antibodies: timing is everything

Zelda Euler et al. Front Immunol. .

Abstract

The recent surge of research into new broadly neutralizing antibodies in HIV-1 infection has recharged the field of HIV-1 vaccinology. In this review we discuss the currently known broadly neutralizing antibodies and focus on factors that may shape these antibodies in natural infection. We further discuss the role of these antibodies in the clinical course of the infection and consider immunological obstacles in inducing broadly neutralizing antibodies with a vaccine.

Keywords: HIV-1; HIV-1 disease progression; broadly neutralizing antibodies; cross-reactive broadly neutralizing antibodies; humoral immunity.

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Figures

FIGURE 1
FIGURE 1
Sequentially elicited antibodies to HIV-1 envelope over the course of the infection.
FIGURE 2
FIGURE 2
Epitope specificity of known broadly neutralizing antibodies to HIV-1 envelope. Adapted from White et al. (2010).
See this image and copyright information in PMC

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