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Clinical Trial
. 1990 Nov;53(11):948-50.
doi: 10.1136/jnnp.53.11.948.

Diurnal differences in response to oral levodopa

J P Frankel  1 , Z Pirtosek, P A Kempster, M Bovingdon, R Webster, A J Lees, G M Stern
Affiliations
Clinical Trial

Diurnal differences in response to oral levodopa

J P Frankel et al. J Neurol Neurosurg Psychiatry. 1990 Nov.

Abstract

Diurnal differences in duration and quality of motor response to levodopa are frequently described by patients. The quality and duration of motor responses were objectively assessed to morning and afternoon oral levodopa doses in five patients with Parkinsonian motor fluctuations who complained of diurnal variation in response to their normal levodopa medication. Results suggest that under controlled conditions which eliminated the effects of diet and overlapping levodopa effects the response to levodopa remained unchanged throughout the day, and that the duration of response could be predicted by plasma levodopa levels.

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