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Review
. 2012 May;32(3):261-8.
doi: 10.1016/j.semnephrol.2012.04.005.

Sugar, sex, and TGF-β in diabetic nephropathy

Maggie K Diamond-Stanic  1 , Young H You, Kumar Sharma
Affiliations
Review

Sugar, sex, and TGF-β in diabetic nephropathy

Maggie K Diamond-Stanic et al. Semin Nephrol. 2012 May.

Abstract

TGF-β is well known to play a critical role in diabetic kidney disease, and ongoing clinical studies are testing the potential therapeutic promise of inhibiting TGF-β production and action. An aspect of TGF-β action that has not received much attention is its potential role in explaining sex-related proclivity for kidney disease. In this review, we discuss recent studies linking TGF-β signaling to sex-related effects in diabetic kidney disease and suggest targets for future studies.

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Conflict of interest statement

Conflict of interest statement: none.

Figures

Figure 1
Figure 1
Mechanisms of prevention of diabetic kidney disease by estrogen. ECM, extracellular matrix; ?, hypothesized effect.
Figure 2
Figure 2
Interactions between TGF-β, AMPK, and mTOR in diabetic kidney disease. TAK1, TGF-β–activated kinase 1,?, hypothesized effect; dashed line, protein-protein interaction.
See this image and copyright information in PMC

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