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Review
. 2012 Jul;56(3):639-49.
doi: 10.1016/j.cden.2012.05.005.

Regenerative endodontics: barriers and strategies for clinical translation

Jeremy J Mao  1 , Sahng G Kim, Jian Zhou, Ling Ye, Shoko Cho, Takahiro Suzuki, Susan Y Fu, Rujing Yang, Xuedong Zhou
Affiliations
Review

Regenerative endodontics: barriers and strategies for clinical translation

Jeremy J Mao et al. Dent Clin North Am. 2012 Jul.

Abstract

Regenerative endodontics has encountered substantial challenges toward clinical translation. The adoption by the American Dental Association of evoked pulp bleeding in immature permanent teeth is an important step for regenerative endodontics. However, there is no regenerative therapy for most endodontic diseases. Simple recapitulation of cell therapy and tissue engineering strategies that are under development for other organ systems has not led to clinical translation in regeneration endodontics. Recent work using novel biomaterial scaffolds and growth factors that orchestrate the homing of host endogenous cells represents a departure from traditional cell transplantation approaches and may accelerate clinical translation.

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Conflict of interest statement

Conflict of Interest

Columbia University is the owner of patents for several regenerative endodontic agents and methods on behalf of Dr. Jeremy Mao’s laboratory.

References

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