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. 2012 Sep:55:58-66.
doi: 10.1016/j.ejmech.2012.07.001. Epub 2012 Jul 15.

Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2

Ubaldina Galli  1 , Ornella Mesenzani, Camilla Coppo, Giovanni Sorba, Pier Luigi Canonico, Gian Cesare Tron, Armando A Genazzani
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Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2

Ubaldina Galli et al. Eur J Med Chem. 2012 Sep.

Abstract

As part of an effort to identify novel selective modulators of sirtuins, we synthesized and tested several isosteres and constrained analogues of nicotinamide. Biological data suggest that compound 2 is selective for Sirt3 over Sirt1 and Sirt2.

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