Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Practice Guideline
. 2012 Dec;23(12):2769-74.
doi: 10.1007/s00198-012-2093-8. Epub 2012 Jul 27.

Treatment failure in osteoporosis

A Diez-Perez  1 , J D Adachi, D Agnusdei, J P Bilezikian, J E Compston, S R Cummings, R Eastell, E F Eriksen, J Gonzalez-Macias, U A Liberman, D A Wahl, E Seeman, J A Kanis, C Cooper; IOF CSA Inadequate Responders Working Group
Affiliations
Practice Guideline

Treatment failure in osteoporosis

A Diez-Perez et al. Osteoporos Int. 2012 Dec.

Abstract

Guidelines concerning the definition of failure of therapies used to reduce the risk of fracture are provided.

Introduction: This study aims to provide guidelines concerning the definition of failure of therapies used to reduce the risk of fracture.

Methods: A working group of the Committee of Scientific Advisors of the International Osteoporosis Foundation was convened to define outcome variables that may assist clinicians in decision making.

Results: In the face of limited evidence, failure of treatment may be inferred when two or more incident fractures have occurred during treatment, when serial measurements of bone remodelling markers are not suppressed by anti-resorptive therapy and where bone mineral density continues to decrease.

Conclusion: The provision of pragmatic criteria to define failure to respond to treatment provides an unmet clinical need and may stimulate research into an important issue.

PubMed Disclaimer

Comment in

  • Treatment failure in osteoporosis.
    Pines A. Pines A. Climacteric. 2012 Dec;15(6):632-3. doi: 10.3109/13697137.2012.733634. Climacteric. 2012. PMID: 23174020 No abstract available.

References

    1. J Bone Miner Res. 2003 Jun;18(6):1051-6 - PubMed
    1. Osteoporos Int. 2002 Aug;13(8):624-9 - PubMed
    1. Ann Rheum Dis. 2004 Mar;63(3):285-9 - PubMed
    1. J Bone Miner Res. 2002 Jan;17(1):1-10 - PubMed
    1. BMJ. 2009 Jun 23;338:b2266 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources