Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2012 Dec;20(12):2431-7.
doi: 10.1038/oby.2012.162. Epub 2012 Jun 22.

Copy number variations associated with obesity-related traits in African Americans: a joint analysis between GENOA and HyperGEN

Wei Zhao  1 , Nathan E Wineinger, Hemant K Tiwari, Thomas H Mosley, Ulrich Broeckel, Donna K Arnett, Sharon L R Kardia, Edmond K Kabagambe, Yan V Sun
Affiliations
Meta-Analysis

Copy number variations associated with obesity-related traits in African Americans: a joint analysis between GENOA and HyperGEN

Wei Zhao et al. Obesity (Silver Spring). 2012 Dec.

Abstract

Obesity is a highly heritable trait and a growing public health problem. African Americans (AAs) are a genetically diverse, yet understudied population with a high prevalence of obesity (BMI >30 kg/m(2)). Recent studies based upon single-nucleotide polymorphisms (SNPs) have identified genetic markers associated with obesity. However, a large proportion of the heritability of obesity remains unexplained. Copy number variation (CNV) has been cited as a possible source of missing heritability in common diseases such as obesity. We conducted a CNV genome-wide association study of BMI in two African-American cohorts from Genetic Epidemiology Network of Arteriopathy (GENOA) and Hypertension Genetic Epidemiology Network (HyperGEN). We performed independent and identical association analyses in each study, then combined the results in a meta-analysis. We identified three CNVs associated with BMI, obesity, and other obesity-related traits after adjusting for multiple testing. These CNVs overlap the PARK2, GYPA, and SGCZ genes. Our results suggest that CNV may play a role in the etiology of obesity in AAs.

PubMed Disclaimer

Figures

Figure 1
Figure 1
The relationship of BMI and the three significant CNVs (CNP11162, CNP10809 and CNP11421). A: Box plots of BMI with different copies of CNVs in GENOA; B: Box plots of BMI with different copies of CNVs in HyperGEN
See this image and copyright information in PMC

References

    1. Flegal KM, Carroll MD, Ogden CL, et al. Prevalence and trends in obesity among US adults 1999–2008. JAMA. 2010;303:235–241. - PubMed
    1. Malnick SD, Knobler H. The medical complications of obesity. QJM. 2006;99:565–579. - PubMed
    1. Flegal KM, Graubard BI, Williamson DF, et al. Cause-specific excess deaths associated with underweight, overweight, and obesity. JAMA. 2007;298:2028–2037. - PubMed
    1. Finkelstein EA, Trogdon JG, Brown DS, et al. The lifetime medical cost burden of overweight and obesity: implications for obesity prevention. Obesity (Silver Spring) 2008;16:1843–1848. - PubMed
    1. Maes HH, Neale MC, Eaves LJ. Genetic and environmental factors in relative body weight and human adiposity. Behav Genet. 1997;27:325–351. - PubMed

Publication types