doi: 10.1126/science.228392.
Intrathecal capsaicin depletes substance P in the rat spinal cord and produces prolonged thermal analgesia
- PMID: 228392
- DOI: 10.1126/science.228392
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Intrathecal capsaicin depletes substance P in the rat spinal cord and produces prolonged thermal analgesia
Science.
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Abstract
A single intrathecal injection of capsaicin depletes substance P from primary sensory neurons and causes a prolonged increase in the thermal and chemical pain thresholds of the rat but no apparent change in responses to noxious mechanical stimuli.
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