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. 1979 Oct 26;206(4417):481-3.
doi: 10.1126/science.228392.

Intrathecal capsaicin depletes substance P in the rat spinal cord and produces prolonged thermal analgesia

T L Yaksh, D H Farb, S E Leeman, T M Jessell

Intrathecal capsaicin depletes substance P in the rat spinal cord and produces prolonged thermal analgesia

T L Yaksh et al. Science. .

Abstract

A single intrathecal injection of capsaicin depletes substance P from primary sensory neurons and causes a prolonged increase in the thermal and chemical pain thresholds of the rat but no apparent change in responses to noxious mechanical stimuli.

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