Maintaining poise: commensal microbiota calibrate interferon responses
- PMID: 22840839
- DOI: 10.1016/j.immuni.2012.07.001
Maintaining poise: commensal microbiota calibrate interferon responses
Abstract
The mechanisms of how commensal bacteria impact systemic immunity are unclear. In this issue of Immunity, Abt et al. (2012) and Ganal et al. (2012) demonstrate that microbiota poise macrophages for induction of the type I interferon pathway after virus infection.
Copyright © 2012 Elsevier Inc. All rights reserved.
Comment on
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Commensal bacteria calibrate the activation threshold of innate antiviral immunity.Immunity. 2012 Jul 27;37(1):158-70. doi: 10.1016/j.immuni.2012.04.011. Epub 2012 Jun 14. Immunity. 2012. PMID: 22705104 Free PMC article.
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Priming of natural killer cells by nonmucosal mononuclear phagocytes requires instructive signals from commensal microbiota.Immunity. 2012 Jul 27;37(1):171-86. doi: 10.1016/j.immuni.2012.05.020. Epub 2012 Jun 28. Immunity. 2012. PMID: 22749822
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