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Case Reports
. 2012 Oct;161(4):760-2.
doi: 10.1016/j.jpeds.2012.05.057. Epub 2012 Jul 27.

Congenital hypothyroidism caused by excess prenatal maternal iodine ingestion

Kara J Connelly  1 , Bruce A Boston, Elizabeth N Pearce, David Sesser, David Snyder, Lewis E Braverman, Sam Pino, Stephen H LaFranchi
Affiliations
Case Reports

Congenital hypothyroidism caused by excess prenatal maternal iodine ingestion

Kara J Connelly et al. J Pediatr. 2012 Oct.

Abstract

We report the cases of 3 infants with congenital hypothyroidism detected with the use of our newborn screening program, with evidence supporting excess maternal iodine ingestion (12.5 mg/d) as the etiology. Levels of whole blood iodine extracted from their newborn screening specimens were 10 times above mean control levels. Excess iodine ingestion from nutritional supplements is often unrecognized.

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Figures

Figure
Figure
Newborn screen serum iodine concentrations. Iodine extracted and measured from newborn screen filter paper samples in 3 CH cases and compared with mean (±SD) serum iodine concentration from control filter paper samples (N = 10).
See this image and copyright information in PMC

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