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Comment
. 2012 Aug 15;31(16):3382-3.
doi: 10.1038/emboj.2012.206. Epub 2012 Jul 27.

A POTluck of peptide transporters

Poul Nissen  1
Affiliations
Comment

A POTluck of peptide transporters

Poul Nissen. EMBO J. .

Abstract

EMBO J (2012) 31 16, 3411–3421 doi:; DOI: 10.1038/emboj.2012.157

EMBO J (2010) 30 2, 417–426 doi:; DOI: 10.1038/emboj.2010.309

The uptake of diet-derived peptides is mediated by the conserved proton-dependent oligopeptide transporter (POT) family. Crystal structures of bacterial transporters in the inward-open conformation and in an occluded conformation published in The EMBO Journal provide structural insight into the proton-driven peptide transport cycle.

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Conflict of interest statement

The author declares that he has no conflict of interest.

Figures

Figure 1
Figure 1
Alternating access mechanism of the proton-dependent oligopeptide transporter (POT) family. To the right, the PEPTSt transporter is shown in the inward-open conformation (Solcan et al, 2012, PDB 4APS), in the middle, the PEPTSo in the inward-occluded conformation (Newstead et al, 2011, PDB 2XUT). To the left, another protein of the Major Facilitator Family, the Fucose transporter is shown in the outward-facing conformation (Dang et al, 2010, PDB 3O7Q).
See this image and copyright information in PMC

Comment on

References

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