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. 2012 Jul;6(3):368-73.
doi: 10.5009/gnl.2012.6.3.368. Epub 2012 Jul 12.

Effect of nonalcoholic Fatty liver disease on the development of type 2 diabetes in nonobese, nondiabetic korean men

Chang Wook Chon  1 , Bum Soo Kim, Yong Kyun Cho, Ki Chul Sung, Ji Cheol Bae, Tae Wan Kim, Hyun Sun Won, Kwan Joong Joo
Affiliations

Effect of nonalcoholic Fatty liver disease on the development of type 2 diabetes in nonobese, nondiabetic korean men

Chang Wook Chon et al. Gut Liver. 2012 Jul.

Abstract

Background/aims: We have a limited understanding of the effect of nonalcoholic fatty liver disease (NAFLD) on the development of type 2 diabetes.

Methods: The study subjects included male who had received biennial medical check-ups between 2005 and 2009 and who had been diagnosed with fatty liver disease. The subjects with sustained NAFLD (FL, n=107) and sustained non-NAFLD (NFL, n=1,054) were followed to determine the development of type 2 diabetes.

Results: In the FL group, there were more subjects with impaired fasting glucose (IFG), type 2 diabetes and high HOMA-IR than there were in the NFL group during the 5-year follow-up period (32.7 vs. 17.6%, 1.9 vs. 0.3%, 17.9 vs. 5.2% respectively, p<0.05). The FL group showed a higher risk than NFL group for abnormal glucose metabolism as determined using IFG (odds ratio [OR], 2.13; confidence interval [CI], 1.36 to 3.35), type 2 diabetes (OR, 7.63; 95% CI, 1.03 to 56.79) and high HOMA-IR (OR, 3.25; 95% CI, 1.79 to 5.91) and metabolic parameters such as body mass index (OR, 3.35; 95% CI, 1.87 to 6.02), triglyceride (OR, 3.05; 95% CI, 1.92 to 4.86) and fasting blood sugar (OR, 2.18; 95% CI, 1.39 to 3.41).

Conclusions: Sustained NAFLD appears to be associated with an increased risk for the development of type 2 diabetes and deterioration of metabolic parameters in non-obese, non-diabetic Korean men.

Keywords: Metabolic syndrome; Nonalcoholic fatty liver disease; Type 2 diabetes mellitus.

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Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1
Fig. 1
Flow of subjects through the study. BMI, body mass index; HDL-C, high-density lipoprotein cholesterol; SBP, systolic blood pressure; DBP, diastolic blood pressure; NAFLD, nonalcoholic fatty liver disease; FL, sustained NAFLD; NFL, sustained non-NAFLD.
Fig. 2
Fig. 2
Correlation between HbA1c level and time in the sustained nonalcoholic fatty liver disease (NAFLD) (FL) and sustained non-NAFLD (NFL) groups after adjustments for age and body mass index during the 5-year follow-up period. The HbA1c and FL statuses were evaluated using one-way repeated measures ANCOVA. The p-values are for the post-hoc analysis of variance comparisons.
See this image and copyright information in PMC

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