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. 2012 Oct;67(10):1316-8.
doi: 10.1111/j.1398-9995.2012.02877.x.. Epub 2012 Jul 30.

Co-factor-enhanced food allergy

V Cardona  1 , O Luengo, T Garriga, M Labrador-Horrillo, A Sala-Cunill, A Izquierdo, L Soto, M Guilarte
Affiliations

Co-factor-enhanced food allergy

V Cardona et al. Allergy. 2012 Oct.

Abstract

Background: Alcohol, exercise or non-steroidal anti-inflamatory drugs (NSAID) are frequently mentioned as amplifiers of food allergic reactions but only individual cases or small series have been previously published.

Methods: Descriptive study including 74 cases of suspected co-factor enhanced food allergy, assessed by skin-prick tests, specific IgE and oral challenges.

Results: Anaphylaxis accounted for 85.1% of reactions. In 99% of cases culprit food allergens were plant-derived, mainly vegetables and cereals. NSAID were involved in 58%, exercise in 52.7% and alcohol in 12.2%. Lipid transfer protein was the most frequently involved allergen.

Conclusions: Co-factor enhanced food allergy should be considered when assessing food, alcohol, exercise and NSAID allergic reactions.

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