Comment
doi: 10.1038/ki.2012.150.
MicroRNAs: a new therapeutic frontier for muscle wasting in chronic kidney disease
- PMID: 22846810
- DOI: 10.1038/ki.2012.150
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Comment
MicroRNAs: a new therapeutic frontier for muscle wasting in chronic kidney disease
Kidney Int.
2012 Aug.
Free article
Abstract
Multiple microRNAs (miRs) are implicated in muscle cell differentiation and muscle mass regulation. Pharmacological agents targeting miR-486 and other miRs, involved in muscle mass regulation, could potentially be developed into therapeutic agents for muscle wasting. Muscle wasting is prevalent among patients with chronic kidney disease (CKD). Xu et al. showed that miR-486 mimetic ameliorated muscle wasting in mice with CKD. miR mimetics may represent a new therapeutic frontier for muscle wasting in CKD.
Comment on
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Transcription factor FoxO1, the dominant mediator of muscle wasting in chronic kidney disease, is inhibited by microRNA-486.Kidney Int. 2012 Aug;82(4):401-11. doi: 10.1038/ki.2012.84. Kidney Int. 2012. PMID: 22475820 Free PMC article.
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