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Case Reports
. 2012;5(6):292-5.
doi: 10.4066/AMJ.2012.987. Epub 2012 Jun 30.

Schmidt's syndrome - Case report

Affiliations
Case Reports

Schmidt's syndrome - Case report

Amit Narayan Gupta et al. Australas Med J. 2012.

Abstract

When immune dysfunction affects two or more endocrine glands and other non-endocrine immune disorders are present, the polyglandular autoimmune (PGA) syndromes should be considered. The PGA syndromes are classified as two main types: PGA type I and PGA type II. We are reporting this case in which a patient had primary adrenal insufficiency, autoimmune hypothyroidism and insulin dependent diabetes mellitus and was diagnosed as "Schmidt's syndrome" (PGA type II). This syndrome is a very rare autoimmune disorder and difficult to diagnose because the symptoms of this syndrome depends on the gland which gets involved first. Our patient was treated and improved with corticosteroid, thyroxine and insulin therapy.

Keywords: Polyglandular; Schmidt's syndrome; autoimmune; autoimmune hypothyroid; insulin dependent diabetes mellitus; primary adrenal insufficiency.

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Conflict of interest statement

CONFLICTS OF INTEREST

None

Figures

Figure 1
Figure 1. Hyperpigmentation over the dorsum of hands.
Figure 2
Figure 2. Hyperpigmentation over the palmer aspect of hands
Figure 3
Figure 3. Hyperpigmentation over the foot
Figure 4
Figure 4. hyperpigmentation over the face

References

    1. Barker JM, Gottlieb PA, Eisenbarth GS. In: Williams Textbook of Endocrinology. Koronenberg H, editor. Philadelphia: Saunders: 2008. The immunoendocrinopathy syndromes. pp. 1754–55.
    1. Addison T. Highley. London: 1855. On the Constitutional and Local Effects of Disease of the Supra-renal Capsules.
    1. Erichsen MM, Løvås K, Skinningsrud B.. Clinical, immunological, and genetic features of autoimmune primary adrenal insufficiency: observations from a Norwegian registry. J Clin Endocrinol Metab. 2009;94:4882. - PubMed
    1. Dittmar M, Kahaly GJ. Polyglandular autoimmune syndromes: immunogenetics and long-term follow-up. J Clin Endocrinol Metab. 2003;88:2983. - PubMed
    1. Neufeld M, Maclaren NK, Blizzard RM. Two types of autoimmune Addison's disease associated with different polyglandular autoimmune (PGA) syndromes. Medicine. 1981;60:355. - PubMed

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