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. 2012 Jul 4;8(3):471-6.
doi: 10.5114/aoms.2012.29402.

A pilot study of circulating PPAR-γ receptor protein in elderly patients with atrial fibrillation

Qing Lin  1 , Lina Jia, Yanshu Sun
Affiliations

A pilot study of circulating PPAR-γ receptor protein in elderly patients with atrial fibrillation

Qing Lin et al. Arch Med Sci. .

Abstract

Introduction: The present study aimed to investigate the relationship between serum peroxisome proliferator-activated receptor-γ (PPAR-γ) protein concentration and inflammatory markers in elderly patients with atrial fibrillation (AF).

Material and methods: We enrolled a total of 73 elderly patients: 45 with AF as the test group and 28 in sinus rhythm as a control group. We assayed serum PPAR-γ receptor protein, high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), and tumour necrosis factor-α (TNF-α). The study protocol and written informed consent were approved by the Ethics Committee of Clinical Research, Peking University First Hospital.

Results: The concentration of PPAR-γ receptor protein was lower in AF patients than that in the control group (p < 0.01), and the concentrations of hs-CRP, IL-6, and TNF-α were higher than those in the control group (all p < 0.01). The PPAR-γ level was negatively correlated with hs-CRP, IL-6, and left atrium diameter (LAD) level (all p < 0.05). On logistic regression analysis, PPAR-γ, hs-CRP, TNF-α and LAD level were associated with AF.

Conclusions: Elderly patients with AF show an inflammatory state and atrial remodeling. The PPAR-γ receptor protein concentration is inversely linked with inflammation in AF. As an important transcription factor regulating inflammatory gene expression, PPAR-γ may take part in the pathogenesis of AF.

Keywords: atrial fibrillation; inflammation; peroxisome proliferator-activated receptor-γ.

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Figures

Figure 1
Figure 1
Serum levels of PPAR-γ and inflammatory factors in controls and patients with paroxysmal and persistent AF. Box plots demonstrate median, and 25th and 75th percentile values
See this image and copyright information in PMC

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