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. 2012 Jul 4;8(3):471-6.
doi: 10.5114/aoms.2012.29402.

A pilot study of circulating PPAR-γ receptor protein in elderly patients with atrial fibrillation

Qing Lin  1 , Lina Jia, Yanshu Sun
Affiliations

A pilot study of circulating PPAR-γ receptor protein in elderly patients with atrial fibrillation

Qing Lin et al. Arch Med Sci. .

Abstract

Introduction: The present study aimed to investigate the relationship between serum peroxisome proliferator-activated receptor-γ (PPAR-γ) protein concentration and inflammatory markers in elderly patients with atrial fibrillation (AF).

Material and methods: We enrolled a total of 73 elderly patients: 45 with AF as the test group and 28 in sinus rhythm as a control group. We assayed serum PPAR-γ receptor protein, high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), and tumour necrosis factor-α (TNF-α). The study protocol and written informed consent were approved by the Ethics Committee of Clinical Research, Peking University First Hospital.

Results: The concentration of PPAR-γ receptor protein was lower in AF patients than that in the control group (p < 0.01), and the concentrations of hs-CRP, IL-6, and TNF-α were higher than those in the control group (all p < 0.01). The PPAR-γ level was negatively correlated with hs-CRP, IL-6, and left atrium diameter (LAD) level (all p < 0.05). On logistic regression analysis, PPAR-γ, hs-CRP, TNF-α and LAD level were associated with AF.

Conclusions: Elderly patients with AF show an inflammatory state and atrial remodeling. The PPAR-γ receptor protein concentration is inversely linked with inflammation in AF. As an important transcription factor regulating inflammatory gene expression, PPAR-γ may take part in the pathogenesis of AF.

Keywords: atrial fibrillation; inflammation; peroxisome proliferator-activated receptor-γ.

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Figures

Figure 1
Figure 1
Serum levels of PPAR-γ and inflammatory factors in controls and patients with paroxysmal and persistent AF. Box plots demonstrate median, and 25th and 75th percentile values
See this image and copyright information in PMC

References

    1. Aksnes TA, Kjeldsen SE, Julius S. Atrial fibrillation and hypertension. Arch Med Sci. 2009;5:S267–72.
    1. Kannel WB, Benjamin EJ. Current perceptions of the epidemiology of atrial fibrillation. Cardiol Clin. 2009;27:13–24. vii. - PMC - PubMed
    1. Banach M, Misztal M, Goch A, Rysz J, Goch JH. Predictors of atrial fibrillation in patients following isolated surgical revascularization. A metaanalysis of 9 studies with 28786 patients. Arch Med Sci. 2007;3:229–39.
    1. Kourliouros A, Savelieva I, Kiotsekoglou A, Jahangiri M, Camm J. Current concepts in the pathogenesis of atrial fibrillation. Am Heart J. 2009;157:243–52. - PubMed
    1. Li J, Solus J, Chen Q, et al. Role of inflammation and oxidative stress in atrial fibrillation. Heart Rhythm. 2010;7:438–44. - PMC - PubMed