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Review
. 2012:2012:960256.
doi: 10.1155/2012/960256. Epub 2012 Jul 12.

In silico modelling of treatment-induced tumour cell kill: developments and advances

Loredana G Marcu  1 , Wendy M Harriss-Phillips
Affiliations
Review

In silico modelling of treatment-induced tumour cell kill: developments and advances

Loredana G Marcu et al. Comput Math Methods Med. 2012.

Abstract

Mathematical and stochastic computer (in silico) models of tumour growth and treatment response of the past and current eras are presented, outlining the aims of the models, model methodology, the key parameters used to describe the tumour system, and treatment modality applied, as well as reported outcomes from simulations. Fractionated radiotherapy, chemotherapy, and combined therapies are reviewed, providing a comprehensive overview of the modelling literature for current modellers and radiobiologists to ignite the interest of other computational scientists and health professionals of the ever evolving and clinically relevant field of tumour modelling.

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Figures

Figure 1
Figure 1
The in silico-in vitro-in vivo chain. The solid arrows illustrate data input whereas the dashed arrows represent the feedback data used for model validation in support of further optimisation.
Figure 2
Figure 2
Tumour growth curves.
Figure 3
Figure 3
Schematic representation of a three-compartment model.
See this image and copyright information in PMC

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